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Elaine Jaffe
Elain Sarkin Jaffe is a senior National Cancer Institute (NCI) investigator at the National Institutes of Health (NIH). She completed her medical education at Cornell University and the University of Pennsylvania, receiving her M.D. from University of Pennsylvania in 1969.〔(【引用サイトリンク】url=https://ccr.cancer.gov/elaine-s-jaffe?qt-staff_profile_tabs=4#qt-staff_profile_tabs )〕 After an internship at Georgetown University she joined NCI as a resident anatomic pathology, and has been a senior investigator since 1974, focusing on the classification and definition of lymphoid neoplasms.〔(【引用サイトリンク】url=https://ccr.cancer.gov/elaine-s-jaffe?qt-staff_profile_tabs=4#qt-staff_profile_tabs )〕 Jaffe's early work helped to provide a much more depth understanding of the origin of lymphomas, particular her work in follicular lymphomas. Her team notably elucidated the difference between T cell and B cell lymphomas.
Her lab's findings led to the development of the WHO Classification of Tumours of the Hematopoetic and Lymphoid Tissues.〔(【引用サイトリンク】url=https://ccr.cancer.gov/elaine-s-jaffe?qt-staff_profile_tabs=0#qt-staff_profile_tabs )〕 Jaffe was the President of the Society of Hematopathology at the time that the WHO's Revised European-American Classification of Lymphoid Neoplasms (REAL) classification system was developed in 1994; the REAL classification system is now considered the gold standard in hematopathology. Today, her research includes genetic and epigenetic studies aimed at understanding how B-cells become Hodgkins lymphoma cells, particularly through the lens of the microenvironment.〔 Jaffe's research has led to improvements in cancer treatments, including disease-specific therapies and improved clinical outcomes.
==Early Life and Career Development==
Jaffe is the daughter of Ukrainian immigrants who fled Russia during World World I.〔 As a child in White Plains, New York, Jaffe was drawn to the sciences, particularly astronomy and geology. In an interview she states, "I fell in love with biology and decided in high school that I was going to become a doctor."〔 She completed her medical education at the University of Pennsylvania in the late 1960s, where she was one of only five women in a class of more than 100 medical students.〔
In her second year of medical school, she met and married her husband Michael Evan Jaffe, then a law student. The family then moved to Washington, D.C., where Jaffe took a residency position at Georgetown University and worked primarily in anatomic pathology. After a year at Georgetown, Jaffe entered an NCI residency program. Dr. Jaffe's early research at NCI helped replace purely descriptive classifications with those based on immunology which helped in the development process leading to today's disease-specific therapies. Jaffe and her fellow NCI researchers showed that red blood cells coated with antibody and erythrocyte-antibody-complement (EAC) adhered to B-cell areas, proving they were lymphocytes derived from the lymphoid follicles.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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